The presentation discusses the hypothesis that Yeniseian, a language family of Central Siberia, is genealogically related to the North American Na-Dene family.  Phonological evidence includes systematic sound correspondences involving consonants and vowels, as well as tones. Morphological evidence involves homologies in finite verb affixes, a shared instrumental suffix in the noun system, and a cognate pattern for forming action nominals from verb stems. Parallel evidence for the Dene-Yeniseian connection from human genetics, ethnography and archaeology is also presented.